Xyloglucan and Concanavalin A based dressings in the topical treatment of mice wound healing process

For medical biomaterials, xyloglucan dispersions can form films or gels to be applied as a wound dressing. this purpose, the structural characterization of dressing (XG) and containing 0.5 mg/mL concanavalin A (XGL) was performed. The lectin release capacity stability, cytotoxicity, pro-wound healing effects were also investigated. XG XGL prepared by mixing % (w/v) with 0.3 (v/v) glycerol. ConA incorporated in maintained its biological activity for fourteen days controlled-release manner. non-toxic, homogeneous, flexible, accelerated contraction compared control group, promoting less infiltration inflammatory cells, angiogenesis, remodeling, early epithelization. alleviate inflammation phase reducing production pro-inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-12), especially film, which promoted up- down-regulation important proteins associated repair. All these findings suggest that may represent good therapeutic approach applications.